2014年8月10日星期日

SphK-I2|cas 312636-16-1| DC Chem|Supplier|Price|Buy  

SphK-I2|cas 312636-16-1| DC Chem|Supplier|Price|Buy
DC Chemicals Supply: SphK-I2|cas 312636-16-1,Purity: >98% ,Cat No. DC7295, In stock.

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SphK-I2|cas 312636-16-1 ,Synonym:  ,Chemical name:  ,Molecular Formula: C15H11ClN2OS ,MW:302.78

SphK-I2, cas 312636-16-1,Purity: >98%, Best Price and quality from DC Chemicals. SKI II is a highly selective and non ATP-competitive S1P receptor inhibitor with IC50 of 0.5 μM, while exhibits no inhibitory on other kinases including PI3K, PKCα and ERK2.

SKI II potently inhibits endogenous SK activities in the breast cancer cell line MDA-MB-231. SKI II demonstrates significantly antiproliferative effects in human cancer cell lines including T-24, MCF-7, MCF-7/VP, NCI/ADR with IC50 of 4.6 μM , 1.2 μM, 0.9 μM and 1.3 μM, respectively. SKI II also induces apoptosis of T24 cells consistent with the hypothesized consequence of reducing S1P levels. [1] As demonstrated previously in MDA-MB-231 cells, SKI II decreases S1P formation in JC cells in a concentration-dependent manner, with IC50 of 12 μM. [2]In addition, SKI-II can reverse drug resistance of SGC7901/DDP to cisplatin by down-regulating expression of P-gp and up-regulating apoptosis through down-regulation of SphK1. [3] SKI II (50 mg/kg) after intraperitoneal or oral administration significantly decreases tumor growth a syngeneic Balb/c mouse solid tumor model that uses JC mammary adenocarcinoma cells relative to control groups with no overt toxicity or weight loss.[2] SKI-II (50 mg/kg ip) ameliorates antigen-induced bronchial smooth muscle hyperresponsiveness in mice by endogenously inhibiting generation of S1P. [4]