SB-408124|cas 288150-92-5| DC Chem|Supplier|Price|Buy  

SB-408124|cas 288150-92-5| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: SB-408124|cas 288150-92-5,Purity: >98% ,Cat No. DC7277, In stock.

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SB-408124|cas 288150-92-5 ,Synonym: SB 408124; SB408124  ,Chemical name: 1-(6,8-difluoro-2-methylquinolin-4-yl)-3-(4-(dimethylamino)phenyl)urea ,Molecular Formula: C19H18F2N4O ,MW:356.37

SB-408124, cas 288150-92-5,Purity: >98%, Best Price and quality from DC Chemicals. SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively; exhibits 50-fold selectivity over OX2 receptor.

SB-408124 binds hypocretin type 1 receptor (HcrtR1) with pKi values of 7.57. Calcium mobilization studies shows that SB-408124 is a functional antagonist of the OX1 receptor with a affinity of approximately 50-fold selectivity over the OX2 receptor. [1] A recent study indicates that pretreatment of primary cultures of rat astrocytes with SB-401824 before Orexin A administration significantly reduced the stimulatory action of Orexin A on both basal and forskolin-acivated cAMP production. [2] SB-408124 (30 μg/10 μL, administered intracerebroventricularly) decreases Orexin-A induced water intake in Wistar rats. Intracerebroventricularly administered Orexin-A (30 μg/10 μL) blocks the vasopressin (VP) level increase induced by either histamine or 2.5% NaCl administration, and this blocking effect is moderated by pretreatment with SB-408124. [3] Intracerebroventricular pretreatment with SB-408124 (50 mM, 5 μL/h) prevents Bicuculline (BIC)-induced increases in endogenous glucose production (EGP). [4]