Ro3280|cas 1062243-51-9| DC Chem|Supplier|Price|Buy  

Ro3280|cas 1062243-51-9| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: Ro3280|cas 1062243-51-9,Purity: >98% ,Cat No. DC7271, In stock.

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Ro3280|cas 1062243-51-9 ,Synonym: Ro 3280; Ro-3280  ,Chemical name: Benzamide,4-[(9-cyclopentyl-7,7-difluoro-6,7,8,9-tetrahydro-5-methyl-6-oxo-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)- ,Molecular Formula: C27H35F2N7O3 ,MW:543.61

Ro3280, cas 1062243-51-9,Purity: >98%, Best Price and quality from DC Chemicals. RO3280 is a potent, highly selective inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 3 nM.

RO3280 shows the strong anti-proliferative activity against lung cancer cell line H82, colorectal cancer cell HT-29, breast cancer cell MDA-MB-468, prostate cancer cell PC3 and skin cancer cell A375 with IC50s of 5, 10, 19, 12 and 70 nM, respectively. RO3280 displays robust antitumor activity in nude mouse implanted with HT-29 human colorectal tumors ranging from 72% tumor growth inhibition when dosed once weekly at 40 mg/kg, to complete tumor regression when dosed more frequently..