Rilpivirine(R 278474, TMC 278) |cas 500287-72-9| DC Chem|Supplier|Price|Buy  

Rilpivirine(R 278474, TMC 278) |cas 500287-72-9| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: Rilpivirine(R 278474, TMC 278) |cas 500287-72-9,Purity: >98% ,Cat No. DC7266, In stock.

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Rilpivirine(R 278474, TMC 278) |cas 500287-72-9 ,Synonym: R 278474; TMC 278; R-278474; R278474; TMC278; TMC-278  ,Chemical name: 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile ,Molecular Formula: C22H18N6 ,MW:366.42

Rilpivirine(R 278474, TMC 278) , cas 500287-72-9,Purity: >98%, Best Price and quality from DC Chemicals. Rilpivirine(R 278474, TMC 278) is a type of anti-HIV medicine called a non-nucleoside reverse transcriptase inhibitor (NNRTI). 

Rilpivirine shows antiviral activity with EC50 ranging from 0.1 nM to 2 nM against wild-type and selected site-directed single and double mutants of HIV-1. [1] Rilpivirine inhibits viral replication at concentrations at which first-generation NNRTIs could not suppress replication, and produces a high genetic barrier to resistance development. [2] After iv administration of Rilpivirine, Elimination half-life ranges from 4.4 h in rat to 31 h in dog. After oral administration of Rilpivirine in PEG 400, half-life ranges between 2.8 h in rat and 39 h in dog. [1]

Features Approved anti-HIV drug with longer half-life and reduced side-effect profile than older NNRTIs.