RGFP 966|cas 1357389-11-7| DC Chem|Supplier|Price|Buy  

RGFP 966|cas 1357389-11-7| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: RGFP 966|cas 1357389-11-7,Purity: >98% ,Cat No. DC7263, In stock.

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RGFP 966|cas 1357389-11-7 ,Synonym: RGFP 966; RGFP-966  ,Chemical name: 2-Propenamide,N-(2-amino-4-fluorophenyl)-3-[1-[(2E)-3-phenyl-2-propen-1-yl]-1H-pyrazol-4-yl]-,(2E)- ,Molecular Formula: C21H19FN4O ,MW:362.4

RGFP 966, cas 1357389-11-7,Purity: >98%, Best Price and quality from DC Chemicals. RGFP966 is specific inhibitor of HDAC3, with an IC50 of 0.08 μM and no effective inhibition of any other HDAC at concentrations up to 15 μM. 

RGFP966 is a slow-on/slow-off, competitive tight-binding HDAC inhibitor, with an IC50 of 0.08μM for HDAC3 and no effective inhibition of any other HDAC at concentrations up to 15μM. [1] RGFP966 treatment on two CTCL cell lines for 24 hours prior to western blot analysis resulted in increased acetylation at H3K9/K14, H3K27, and H4K5, but not H3K56ac. RGFP966 decreases cell growth in CTCL (cutaneous T cell lymphoma) cell lines due to increased apoptosis that is associated with DNA damage and impaired S phase progression. RGFP966 causes a significant reduction in DNA replication fork velocity within the first hour of drug treatment. [2]