Repsox|cas 446859-33-2| DC Chem|Supplier|Price|Buy  

Repsox|cas 446859-33-2| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: Repsox|cas 446859-33-2,Purity: >98% ,Cat No. DC7259, In stock.

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Repsox|cas 446859-33-2 ,Synonym: E-616452; SJN 2511; E616452; SJN2511; E 616452; SJN-2511  ,Chemical name: 1,5-Naphthyridine,2-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]- ,Molecular Formula: C17H13N5 ,MW:287.32

Repsox, cas 446859-33-2,Purity: >98%, Best Price and quality from DC Chemicals. RepSox(E-616452; SJN 2511) is a potent and selective inhibitor of the TGFβR-1/ALK5 with IC50 of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation, respectively.

RepSox inhibits ATP binding to ALK5 and ALK5 autophosphorylation with IC50 of 23 nM and 4 nM, respectively. RepSox inhibits TGF-β induced cellular PAI-1 luciferase activity with IC50 of 18 nM. [1] RepSox is able to successfully replace Sox2 in reprogramming by inhibiting transforming growth factor-β (Tgf-β) signaling, which in turn induces Nanog expression. Effect of RepSox inducing reprogramming does not require chromatin remodeling. RepSox is found to be efficient at generating iPSCs. [2] RepSox is able to be contribute to forming chimeric embryos in vivo when injected into blastocysts. A one-day treatment with RepSox is sufficient to replace transgenic Sox2. [2]