PR-619|cas 2645-32-1| DC Chem|Supplier|Price|Buy  

PR-619|cas 2645-32-1| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: PR-619|cas 2645-32-1,Purity: >98% ,Cat No. DC7252, In stock.

Contact: website: www.dcchemicals.com,

sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,

Tel: +86-21-61454686;Fax:+86-21-61642721；

PR-619|cas 2645-32-1 ,Synonym: 2,6-Diamino-3,5-dithiocyanopyridine; PR 619; PR619  ,Chemical name:  ,Molecular Formula: C7H5N5S2 ,MW:223.28

PR-619, cas 2645-32-1,Purity: >98%, Best Price and quality from DC Chemicals. PR-619 is a broad-range DUB inhibitor with potential for further development as a chemotherapeutic agent in cancer therapy.

PR-619 is a cell-permeable pyridinamine class broad-spectrum DUB inhibitor whose known targets include ATXN3, BAP1, JOSD2, OTUD5, UCH-L1, UCH-L3, UCH-L5/UCH37, USP1, 2, 4, 5, 7, 8, 9X, 10, 14, 15, 16, 19, 20, 22, 24, 28, 47, 48, VCIP135, YOD1, as well as deISGylase PLpro, deNEDDylase DEN1, and deSUMOlyase SENP6. PR-619 are shown to increase overall protein polyubiquitination in HEK293T cells in a dose- and time-dependent manner (20 to 150 μM, 0.5 to 20 h). PR619 treatment results in upregulation of both K 48 - and K63-linked polyUb chains. PR-619 induces HCT116 cell death with EC50 values of 6.3 μM.[1]