PIK-294|cas 900185-02-6| DC Chem|Supplier|Price|Buy  

PIK-294|cas 900185-02-6| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: PIK-294|cas 900185-02-6,Purity: >98% ,Cat No. DC7234, In stock.

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PIK-294|cas 900185-02-6 ,Synonym: PIK294,PIK 294 ,Chemical name: 2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one ,Molecular Formula: C28H23N7O2 ,MW:489.53

PIK-294, cas 900185-02-6,Purity: >98%, Best Price and quality from DC Chemicals. PIK-294 is a highly selective p110δ inhibitor with IC50 of 10 nM, 1000-, 49- and 16-fold less potent to PI3Kα/β/γ, respectively.

PIK-294 shows distinct patterns of isoform selectivity to inhibit different subsets of class I PI3K isoforms (p110β, p110δ, and p110γ) and exhibits low sensitivity to p110α with IC50 of 10 μM). The m-phenol moiety of PIK-294 is able to penetrate the deep-affinity pocket of the ATP binding site, and thus increases in vitro inhibitory activity. [1]