Conduritol B Epoxide (CBE) |inhibitor of β-glucosidase|DC Chemicals
Conduritol B Epoxide (CBE) is a specific covalent inhibitor of β-glucosidase which results in the accumulation of glucocerebroside.
Product Name: Conduritol B Epoxide（CBE） |Catalog Number: DC8340 | cas: 6090-95-5 | Other names: Conduritol C epoxide | Chemical name：D,L-1,2-Anhydro-myo-inositol; 1,2-Anhydro-myo-inositol; Conduritol B-epoxide; Conduritol C epoxide
| Molecule Formula: C6H10O5 | MW: 162.14
Conduritol B Epoxide (CBE) is a specific covalent inhibitor of β-glucosidase which results in the accumulation of glucocerebroside. Treatment of murine peritoneal macrophages with this inhibitor does not seem to affect lysozyme enzyme release to the medium, cell viability, or levels of intracellular lysosomal enzymes, other than &beta-glucosidase activity. In vitro exposure of cells to CBE has been reported to lead to up-regulation of CD1d (cluster of differentiation 1d) expression by THP-1 cells, which is related to an increase in mRNA expression.
For research and scientific purpose only, not for human use.
2015年10月25日星期日
MPEP-HCl| mGlu5a receptor inhibitor|DC Chemicals
MPEP-HCl| mGlu5a receptor inhibitor|DC Chemicals
MPEP is a potent, highly selective non-competitive antagonist at the mGlu5a receptor subtype (IC50 = 36 nM) while having no agonist or antagonist activities at the mGlu1b receptor at concentrations up to 30 μM.
Product Name: MPEP hydrochloride |Catalog Number: DC8339 | cas: 219911-35-0 | Other names: | Chemical name：2-Methyl-6-(phenylethynyl)pyridine hydrochloride | Molecule Formula: C14H11N.HCl | MW: 229.71
Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.
For research and scientific purpose only, not for human use.
MPEP is a potent, highly selective non-competitive antagonist at the mGlu5a receptor subtype (IC50 = 36 nM) while having no agonist or antagonist activities at the mGlu1b receptor at concentrations up to 30 μM.
Product Name: MPEP hydrochloride |Catalog Number: DC8339 | cas: 219911-35-0 | Other names: | Chemical name：2-Methyl-6-(phenylethynyl)pyridine hydrochloride | Molecule Formula: C14H11N.HCl | MW: 229.71
Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.
For research and scientific purpose only, not for human use.
Azeliragon（PF-04494700,TTP488）|RAGE inhibitor|Alzheimer research
Azeliragon（PF-04494700,TTP488）|RAGE inhibitor|Alzheimer research| cas: 603148-36-3|DC Chemicals
Azeliragon is an oral, small-molecule inhibitor of RAGE.
Product Name: Azeliragon（PF-04494700,TTP488） |Catalog Number: DC8338 | cas: 603148-36-3 | Other names: PF04494700,TTP-488,PF 04494700,TTP 488,PF-,04494700TTP488 | Chemical name：3-(4-{2-butyl-1-[4-(4-chlorophenoxy)phenyl]-1H-imidazol-4-yl}phenoxy)-N,N-diethylpropan-1-amine | Molecule Formula: C32H38ClN3O2 | MW: 532.116
For research and scientific purpose only, not for human use.
Azeliragon is an oral, small-molecule inhibitor of RAGE.
Product Name: Azeliragon（PF-04494700,TTP488） |Catalog Number: DC8338 | cas: 603148-36-3 | Other names: PF04494700,TTP-488,PF 04494700,TTP 488,PF-,04494700TTP488 | Chemical name：3-(4-{2-butyl-1-[4-(4-chlorophenoxy)phenyl]-1H-imidazol-4-yl}phenoxy)-N,N-diethylpropan-1-amine | Molecule Formula: C32H38ClN3O2 | MW: 532.116
For research and scientific purpose only, not for human use.
Fluensulfone|318290-98-1|DC Chemicals
Fluensulfone|318290-98-1|DC Chemicals
Fluensulfone is a new nematicide of the fluoroalkenyl thioether group that has significantly reduced environmental impact with low toxicity to non-target insects and mammals.
Product Name: Fluensulfone |Catalog Number: DC8337 | cas: 318290-98-1 | Other names: | Chemical name：5-Chloro-2-[(3,4,4-trifluorobut-3-en-1-yl)sulfonyl]-1,3-thiazole | Molecule Formula: C7H5ClF3NO2S2 | MW: 291.69
Fluensulfone, a new nematicide of the fluoroalkenyl group, has proved to be very effective in controlling root-knot nematodes, Meloidogyne spp., by soil application. The systemic activity of this compound against M. incognita on peppers via soil drenching and foliar spray was evaluated.
Systemic nematicidal activity of fluensulfone against the root-knot nematode Meloidogyne incognita on pepper. Available from: http://www.researchgate.net/publication/51572337_Systemic_nematicidal_activity_of_fluensulfone_against_the_root-knot_nematode_Meloidogyne_incognita_on_pepper [accessed Sep 17, 2015].
For research and scientific purpose only, not for human use.
Fluensulfone is a new nematicide of the fluoroalkenyl thioether group that has significantly reduced environmental impact with low toxicity to non-target insects and mammals.
Product Name: Fluensulfone |Catalog Number: DC8337 | cas: 318290-98-1 | Other names: | Chemical name：5-Chloro-2-[(3,4,4-trifluorobut-3-en-1-yl)sulfonyl]-1,3-thiazole | Molecule Formula: C7H5ClF3NO2S2 | MW: 291.69
Fluensulfone, a new nematicide of the fluoroalkenyl group, has proved to be very effective in controlling root-knot nematodes, Meloidogyne spp., by soil application. The systemic activity of this compound against M. incognita on peppers via soil drenching and foliar spray was evaluated.
Systemic nematicidal activity of fluensulfone against the root-knot nematode Meloidogyne incognita on pepper. Available from: http://www.researchgate.net/publication/51572337_Systemic_nematicidal_activity_of_fluensulfone_against_the_root-knot_nematode_Meloidogyne_incognita_on_pepper [accessed Sep 17, 2015].
For research and scientific purpose only, not for human use.
Tizoxanide|inhibitor of hepatitis B virus and hepatitis C virus
Tizoxanide|inhibitor of hepatitis B virus and hepatitis C virus cas: 173903-47-4 | DC Chemicals
Tizoxanide is a potent inhibitor of hepatitis B virus and hepatitis C virus.
Product Name: Tizoxanide |Catalog Number: DC8336 | cas: 173903-47-4 | Other names: | Chemical name： | Molecule Formula: C10H7N3O4S | MW: 265.3
Tizoxanide is the active metabolite of nitazoxanide, an anti-infective that has been approved for the treatment of diarrhea caused by Giardia lamblia or Crytosporidium parvum.Tizoxanide is active against anaerobic bacteria, protozoan parasites, and viruses. It reduces the growth of the disease-causing parasites, L. mexicana and T. cruzi, in vitro (IC50s = 6.2 and 17.5 μM, respectively),inhibits influenza A replication (EC50s = 0.3-1 μM), and inhibits hepatitis B and hepatitis C virus replication (EC50s both = 0.15 μM).
For research and scientific purpose only, not for human use.
Tizoxanide is a potent inhibitor of hepatitis B virus and hepatitis C virus.
Product Name: Tizoxanide |Catalog Number: DC8336 | cas: 173903-47-4 | Other names: | Chemical name： | Molecule Formula: C10H7N3O4S | MW: 265.3
Tizoxanide is the active metabolite of nitazoxanide, an anti-infective that has been approved for the treatment of diarrhea caused by Giardia lamblia or Crytosporidium parvum.Tizoxanide is active against anaerobic bacteria, protozoan parasites, and viruses. It reduces the growth of the disease-causing parasites, L. mexicana and T. cruzi, in vitro (IC50s = 6.2 and 17.5 μM, respectively),inhibits influenza A replication (EC50s = 0.3-1 μM), and inhibits hepatitis B and hepatitis C virus replication (EC50s both = 0.15 μM).
For research and scientific purpose only, not for human use.
PI3K-IN-2|cas 1225037-39-7|DC Chemicals
PI3K-IN-2|cas 1225037-39-7|DC Chemicals
PI3K-IN-2 is a PI3K inhibitor, inhibits pPKB and pS6 with "++++/+++(+)" in A2058 melanoma cell.
Product Name: PI3K-IN-2 |Catalog Number: DC8335 | cas: 1225037-39-7 | Other names: | Chemical name： | Molecule Formula: C17H20F3N7O2 | MW: 411.38
PI3K-IN-2 is a PI3K inhibitor, inhibits pPKB and pS6 with "++++/+++(+)" in A2058 melanoma cell.
For research and scientific purpose only, not for human use.
Docetaxel Trihydrate|cas 148408-66-6 |DC Chemicals
Docetaxel Trihydrate|cas 148408-66-6 |DC Chemicals
Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
Product Name: Docetaxel Trihydrate |Catalog Number: DC8416 | cas: 148408-66-6 | Other names: | Chemical name：(αR,βS)-β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-benzenepropanoic acid, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester,hydrate (1:3) | Molecule Formula: C43H53NO14.3H2O | MW: 861.93
Docetaxel is a cytotoxic agent, especially for proliferating cells, which is related to its ability to promote the formation of microtubule bundles and induce sustained mitotic arrest, followed by apoptosis of mitotically arrested cells or permanent mitotic block. Docetaxel suppresses microtubule dynamic instability as well as tread-milling, resulting in the failure of chromosomes to segregate to the daughter cells, which in turn triggers premature exit from mitosis rather than a block at this phase of the cell cycle. [2] Docetaxel inhibits the clonogenic survival of Human cancer cell Hs746T (stomach), AGS (stomach), HeLa (cervix), CaSki (cervix), BxPC3 (pancreas), Capan-1 (pancreas) with IC50 of 1 nM, 1 nM, 0.3 nM, 0.3 nM, 0.3 nM and 0.3 nM respectively. [4] Docetaxel inhibits endothelial cell migration that does not affects microtubule gross morphology or inhibit cell proliferation, although they does produce more subtle effects on microtubule dynamics. Docetaxel inhibits HUVEC migration with an observed IC50 of 1 pM. HUVEC chemotaxis stimulated by either of two angiogenic factors, thymidine phosphorylase or VEGF, is inhibited by Docetaxel with IC 50 of 10 pM and is ablated at 1 nM. [7] Docetaxel induces human monocytes, but not RAW 264.7 murine macrophages, Prostaglandin H Synthase-2m (PGHS-2) expression. [8]Docetaxel (33 mg/kg/dose, given i.v. every 4 days for 3 injections) results in a tumor growth delay of 19.3 days in M2OL2 colon xenografts. Docetaxel also shows great antitumor activities in MX-1, SK-MEL-2, LX-1 and OVCAR-3 xenografts. Docetaxel inhibits the angiogenic response to fibroblast growth factor 2 with IC 50 of 5.4 mg/kg when injected twice weekly over a 14-day period, and angiogenesis is completely blocked in mice that receives 10 mg/kg Docetaxel. Docetaxel has selectivity for endothelial cell migration and/or microvessel formation because infiltration of inflammatory cells into the Matrigel plug is much less sensitive to inhibition by Docetaxel. [7]
For research and scientific purpose only, not for human use.
Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
Product Name: Docetaxel Trihydrate |Catalog Number: DC8416 | cas: 148408-66-6 | Other names: | Chemical name：(αR,βS)-β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-benzenepropanoic acid, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester,hydrate (1:3) | Molecule Formula: C43H53NO14.3H2O | MW: 861.93
Docetaxel is a cytotoxic agent, especially for proliferating cells, which is related to its ability to promote the formation of microtubule bundles and induce sustained mitotic arrest, followed by apoptosis of mitotically arrested cells or permanent mitotic block. Docetaxel suppresses microtubule dynamic instability as well as tread-milling, resulting in the failure of chromosomes to segregate to the daughter cells, which in turn triggers premature exit from mitosis rather than a block at this phase of the cell cycle. [2] Docetaxel inhibits the clonogenic survival of Human cancer cell Hs746T (stomach), AGS (stomach), HeLa (cervix), CaSki (cervix), BxPC3 (pancreas), Capan-1 (pancreas) with IC50 of 1 nM, 1 nM, 0.3 nM, 0.3 nM, 0.3 nM and 0.3 nM respectively. [4] Docetaxel inhibits endothelial cell migration that does not affects microtubule gross morphology or inhibit cell proliferation, although they does produce more subtle effects on microtubule dynamics. Docetaxel inhibits HUVEC migration with an observed IC50 of 1 pM. HUVEC chemotaxis stimulated by either of two angiogenic factors, thymidine phosphorylase or VEGF, is inhibited by Docetaxel with IC 50 of 10 pM and is ablated at 1 nM. [7] Docetaxel induces human monocytes, but not RAW 264.7 murine macrophages, Prostaglandin H Synthase-2m (PGHS-2) expression. [8]Docetaxel (33 mg/kg/dose, given i.v. every 4 days for 3 injections) results in a tumor growth delay of 19.3 days in M2OL2 colon xenografts. Docetaxel also shows great antitumor activities in MX-1, SK-MEL-2, LX-1 and OVCAR-3 xenografts. Docetaxel inhibits the angiogenic response to fibroblast growth factor 2 with IC 50 of 5.4 mg/kg when injected twice weekly over a 14-day period, and angiogenesis is completely blocked in mice that receives 10 mg/kg Docetaxel. Docetaxel has selectivity for endothelial cell migration and/or microvessel formation because infiltration of inflammatory cells into the Matrigel plug is much less sensitive to inhibition by Docetaxel. [7]
For research and scientific purpose only, not for human use.
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