VU6005649|VU-6005649|cas 2137047-43-7
DC Chemicals, Website:www.dcchemicals.com
Product Name: VU6005649|CAS: 2137047-43-7|Cat No: DC10717|Other Names: VU6005649; VU-6005649; VU 6005649
VU6005649 is a dual mGlu7/8 positive allosteric modulator with EC50s of 649 nM and 2.6 μM for mGlu7 and mGlu8, respectively.
VU6005649 is a potent and CNS Penetrant mGlu7/8 Receptor PAM (mGlu7, IC50 = 649 nM; mGlu4, IC50 = 10 nM; mGlu8, IC50 = 2.6nM). VU6005649 demonstrates in vivo efficacy in a mouse contextual fear conditioning model.
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