ML-239|ML239|CAS 1378872-36-6

ML-239|ML239|CAS 1378872-36-6

DC Chemicals, Website:www.dcchemicals.com

Product Name: ML-239|CAS: 1378872-36-6|Cat No: DC10790|Other Names: CID-49843203,CID 49843203,CID49843203,ML-239,ML 239,ML239,1378872-36-6

ML-239 is an inhibitor of cancer stem cells, displaying greater than 23-fold selective inhibition of a breast cancer stem cell-like cell line (EC50 = 1.18 µM) over an isogenic control cell line (EC50 = 27.6 µM).

ML239 (Compound 7j) is a potent and selective inhibitor of breast cancer stem cells, with an IC50 of 1.16 μM, with ∼24-fold selectivity against the control cell line. ML239 inhibits breast cancer stem-like cells, most likely through activation of fatty acid desaturase 2 (FADS2). ML239 is cytotoxic to NCIH661 cells, and FADS2 knockdown reduces ML239 cytotoxicity, and furthermore, FADS2 inhibitor SC-26196 also reduces ML239 cytotoxicity in cancer cell lines (CCLs).