CaCC(inh)-A01|TMEM16 Blocker I|cas 407587-33-1
DC Chemicals, Website:www.dcchemicals.com
Product Name: CaCC(inh)-A01|CAS: 407587-33-1|Cat No: DC10736|Other Names: TMEM16 Blocker I
CaCC(inh)-A01 is a non-selective inhibitor of calcium-activated chloride channels (CaCCs) that blocks ATP-stimulated chloride conductance in human salivary gland, intestinal, and bronchial epithelium (mean IC50 = 10 µM).
CaCC(inh)-A01 (30 µM) induces full vasorelaxation of preconstricted mouse isolated mesenteric arteries in the presence or absence of chloride.CaCC(inh)-A01 also attenuates CaCC TMEM16-A-induced proliferation in cancer cell lines through targeted degradation of the protein and reduces BKCa channel activity in human red blood cells.
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