DIM-C-pPhOCH3(C-DIM5)|Nur77 antagonist|CAS 151358-47-3

DIM-C-pPhOCH3(C-DIM5)|Nur77 antagonist|CAS 151358-47-3

DC Chemicals, Website:www.dcchemicals.com

Product Name: DIM-C-pPhOCH3(C-DIM5)|CAS: 33985-68-1|Cat No: DC10792|Other Names:

C-DIM5 is a Nur77 agonist. Activation of the orphan nuclear receptor Nur77 by C-DIM5 is associated with decreased cancer cell survival,

C-DIM5 is a Nur77 agonist. Activation of the orphan nuclear receptor Nur77 by C-DIM5 is associated with decreased cancer cell survival, induction of apoptosis, induced expression of the apoptosis gene/protein TRAIL, and inhibited tumor growth in vivo. C-DIM5 induces G0-G1–phase to S-phase arrest in Panc1 cells, and this is accompanied by Nur77-dependent induction of the cyclin-dependent kinase inhibitor p21.