CM-272|CM272|CAS 1846570-31-7

CM-272|CM272|CAS 1846570-31-7

DC Chemicals, Website:www.dcchemicals.com

Product Name: CM-272|CAS: 1846570-31-7|Cat No: DC10795|Other Names: CM-272; CM 272; CM272

CM-272 is a first-in-class reversible dual small molecule inhibitor against G9a and DNMTs in hematological malignancies.

CM-272 is a first-in-class reversible and substrate-competitive dual inhibitor of G9a and DNMTs. In ALL, AML and DLBCL-derived cell lines, CM-272 reduced DNA methylation in the promoter region of specific tumor suppressor genes. CM-272 also inhibited cell proliferation, blocked cell cycle progression and induced apoptosis in a dose-dependent way.