KDU691|KDU-691|cas 1513879-19-0
DC Chemicals, Website:www.dcchemicals.com
Product Name: ML355|CAS: 1532593-30-8|Cat No: DC10747|Other Names: ML 355,ML-355,ML355
ML355 is a potent and selective inhibitors of 12-Lipoxygenase(12-LOX) with IC50 of 0.34 μM, excellent selectivity over related lipoxygenases and cyclooxygenases, and possess favorable ADME properties.
ML355 is a selective inhibitor of 12-LO with an IC50 value of 0.34 µM.It demonstrates greatly reduced potency for 15-LO-1, 15-LO-2, and 5-LO (IC50s = 9.7, >100, and >100 µM) and no inhibition of COX-1 and -2. In cell-based assays, ML355 has been shown to decrease calcium mobilization and thrombin receptor PAR4-induced platelet aggregation in patient-derived human platelets and to significantly inhibit arachidonic acid and calcium- ionophore-induced 12-HpETE synthesis in mouse BTC3 cells and human islets.
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