MRT67307 HCl|cas 1190378-57-4

MRT67307 HCl|cas 1190378-57-4

DC Chemicals, Website:www.dcchemicals.com

Product Name: MRT67307 HCl|CAS: 1190378-57-4|Cat No: DC10635|Other Names:

MRT67307 is a potent and dual IKKϵ and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively.

In vitro:
In macrophages, MRT67307 prevents the phosphorylation of IRF3 and the production of IFNβ. In wild-type MEFs, MRT67307 enhances the IL-1-stimulated phosphorylation of p105 at Ser933 and RelA at both Ser468 and Ser536, and also enhances IL-1-stimulated activation of NF-κB-dependent gene transcription.MRT67307 increases IL-10 production and suppresses proinflammatory cytokine production via a cAMP response element-Binding protein (CREB)-regulated transcriptional coactivator (CRTC) 3 Dependent Mechanism.In addition, MRT67307 inhibit ULK and block autophagy in MEF cells.