GSK3326595(EPZ015938)|cas 1616392-22-3|PRMT5 inhibitor

GSK3326595(EPZ015938)|cas 1616392-22-3|PRMT5 inhibitor

DC Chemicals, Website:www.dcchemicals.com

Product Name: GSK3326595(EPZ015938)|CAS: 1616392-22-3|Cat No: DC10647|Other Names: GSK-3326595; GSK 3326595; GSK3326595; EPZ015938; EPZ 015938; EPZ-015938

GSK3326595(EPZ015938) is the first-in-class protein arginine methyltransferase-5 (PRMT5) inhibitor.

PRMT5 is a protein arginine methyltransferase (PRMT) that is reported to have a role in diverse cellular processes, including tumorigenesis. PRMT5 overexpression is observed in cell lines and primary patient samples derived from a number of cancers, including lymphomas, lung cancer, breast cancer and colorectal cancer. GSK3326595 (formerly EPZ015938), a highly selective and orally bioavailable small molecule, is the first PRMT5 inhibitor and the third epigenetic investigational therapy derived from Epizyme’s proprietary discovery platform to enter the clinic.