AX 15836|AX15836|ERK5 inhibitor

AX 15836|AX15836|ERK5 inhibitor

DC Chemicals, Website:www.dcchemicals.com

Product Name: AX15836|CAS: N/A|Cat No: DC10649|Other Names: AX15836; AX 15836; AX-15836

AX15836 is a highly potent and selective ERK5 inhibitor.

Potent and selective ERK5 inhibitor (IC50 = 8 nM). Exhibits >1,000-fold selectivity for ERK5 over a panel of over 200 kinases. Also exhibits selectivity over bromodomain BRD4 (Kd = 3,600 nM). Increases vomocytosis in human macrophages in vitro, as well as in an in vivo zebrafish model of cryptococcal disease, reducing spread of infection.