PF-04418948,PF04418948|EP2 receptor inhibitor|DC Chemicals

PF-04418948,PF04418948|EP2 receptor inhibitor|DC Chemicals

PF-04418948 is an orally active, potent, and selective EP2 receptor antagonist (IC50 = 16 nM).

Product Name: PF-04418948 |Catalog Number: DC8353 |CAS 1078166-57-0 |Other names: PF-04418948,PF04418948,PF 04418948 |Chemical Name: 1-(4-Fluorobenzoyl)-3-[[(6-methoxy-2-naphthalenyl)oxy]methyl]-3-azetidinecarboxylic acid |Molecule Formular: C23H20FNO5 |MW: 409.41

Potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors; exhibits <30% binding at a diverse panel of GPCRs and ion channels at a concentration of 10 μM. Inhibits PGE2-induced increases in intracellular cAMP; reverses PGE2-invoked relaxation of mouse trachea (IC50 = 2.7 nM). For the detailed information of PF-04418948, the solubility of PF-04418948 in water, the solubility of PF-04418948 in DMSO, the solubility of PF-04418948 in PBS buffer, the animal experiment (test) of  PF-04418948, the cell expriment (test) of PF-04418948, the in vivo, in vitro and clinical trial test of PF-04418948, the EC50, IC50,and affinity,of PF-04418948, For the detailed information of PF-04418948, the solubility of PF-04418948 in water, the solubility of PF-04418948 in DMSO, the solubility of PF-04418948 in PBS buffer, the animal experiment (test) of  PF-04418948, the cell expriment (test) of PF-04418948, the in vivo, in vitro and clinical trial test of PF-04418948, the EC50, IC50,and affinity,of PF-04418948, Please contact DC Chemicals.

For research and scientific purpose only, not for human use.