IEM 1754 2HBr is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.
Product Name: IEM 1754 DihydrobroMide |Catalog Number: DC8769 |CAS 162831-31-4 |Other names: IEM1754 dihydrobromide;IEM1754 2 HBr; AOB5933; |Chemical Name: |Molecule Formular: C16H32Br2N2 |MW: 412.25
IEM 1754 is an adamantane derivative. IEM 1754 causes use- and voltage-dependent block of open channels of recombinant AMPA receptors. This antagonism is dependent on receptor subunit composition, channels gated by recombinant, homomeric GluR1 and GluR3 receptors exhibites a higher sensitivity to block than those gated by receptors containing edited GluR2 subunits.IEM-1754 block of GluR2-containing AMPAR is enhanced by hyperpolarization in agreement with the classical single-exponential model. In contrast, the block of GluR2-lacking AMPAR is reduced by hyperpolarization.
For research only, not for human use!
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