NSC 23766 is a specific inhibitor of the binding and activation of Rac GTPase.
Product Name: NSC 23766 |Catalog Number: DC8725 |CAS 1177865-17-6 |Other names: NSC 23766,NSC23766,NSC-23766 |Chemical Name: N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride |Molecule Formular: C24H35N7.3HCl |MW: 530.97
NSC 23766 is a specific inhibitor of the binding and activation of Rac GTPase. In vitro studies have shown that NSC 23766 inhibits Rac 1 binding and activation via Rac-specific GEF Trio or Tiam 1 without altering RhoA or CDC42 binding or activation. Membrane type 1-matrix metalloproteinases (MT-1MMP) expression in CB CD34+ cells has been reported to decrease in the presence of NSC 23766. Silveta compressa investigations indicate that NSC 23766 depolarizes endomembrane cycling, altered polar adhesive secretion, and tip growth.
For research and scientific purpose only, not for human use!
没有评论:
发表评论