Sirtinol is a cell-permeable, specific inhibitor of sirtuin NAD-dependant histone deacetylases.
Product Name: Sirtinol |Catalog Number: DC8721 |CAS 410536-97-9 |Other names: Sir Two Inhibitor Naphthol |Chemical Name: 2-[[(2-hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)-benzamide |Molecule Formular: C26H22N2O2 |MW: 394.47
Sirtinol is a cell-permeable, specific inhibitor of sirtuin NAD-dependant histone deacetylases. Sirtinol has been shown to inhibit yeast Sir2 (IC50 = 70 μM), human SIRT2 (IC50 = 40 μM), and human SIRT1 (IC50 = 131 μM), yet has shown no effect on human HDAC1. In Arabidopsis, sirtinol strongly affected root and vascular tissue development by activating the auxin signaling pathway. Sirtinol has also been shown to induce senescence-like growth arrest in human breast cancer MCF-7 and lung cancer H1299 cells by impaired activation of MAPK.
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