IMD-0354|cas 978-62-1|DC Chemicals

IMD-0354|cas 978-62-1|DC Chemicals

IMD-0354 is a synthetic selective NF-kB inhibitor.

Product Name: IMD-0354 |Catalog Number: DC8770 |CAS 978-62-1 |Other names: IKK-2 Inhibitor V; IMD 0354;IMD0354; |Chemical Name:  |Molecule Formular: C15H8ClF6NO2 |MW: 383.67

IMD-0354 is a synthetic selective NF-kB inhibitor.in vitro: IMD-0354 inhibits p65 translocation to the nucleus promoted by FGF2 in PASMCs. Furthermore, the time courses of Erk1/2, MCP-1, and PAI-1 stimulated with FGF2 are each markedly shortened by IMD-0354. IMD-0354 suppresses proliferation and induced apoptosis of PASMCs. IMD-0354 decreases FGF2, PAI-1, t-PA mRNA expressions. IMD-0354 also inhibits the translocation of NF-kB subunit p65 into the nucleus.in vivo: IMD-0354 has potential as a new therapeutic tool for PAH. IMD-0354 improves survival in the PAH rats. IMD-0354 improves physical signs of RVH in the PAH rats. IMD-0354 also decreases medial hypertrophy in the pulmonary arterioles.

For research only, not for human use!