NS 11021 is an activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1).
Product Name: NS 11021 |Catalog Number: DC8789 |CAS 956014-19-0 |Other names: NS11021,NS 11021,NS-11021 |Chemical Name: N'-[3,5-Bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl-phenyl]thiourea |Molecule Formular: C16H9BrF6N6S |MW: 511.24
Activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). Exhibits no modulatory effect on a variety of K+ (KV), Na+ and Ca2+ currents at concentrations <10 μM. Alters gating kinetics, but does not affect single channel conductance. Shown to bind BKCa in open and closed conformations; thought to bind the α subunit.
For research only, not for human use!
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