PU-H71 is a potent Hsp90 inhibitor with IC50 of 50 nM.
Product Name: PU-H71 |Catalog Number: DC8745 |CAS 873436-91-0 |Other names: PU-H 71; PU H71 |Chemical Name: |Molecule Formular: C18H21IN6O2S |MW: 512.37
PU-H71 is a potent Hsp90 inhibitor with IC50 of 50 nM.PU-H71, a novel HSP90 inhibitor in Ewing sarcoma cell lines, Hsp90 plays a critical role in modulating the activity of many cell signaling proteins and are an attractive target for anti-cancer therapeutics. Studies indicate that PU-H71(Hsp90 inhibitors) may serve as potential anti-Parkinson′s disease. PU-H71. Potent and durable anti-tumor effects in TNBC xenografts, including complete response and tumor regression, without toxicity to the host are achieved with this agent. Notably, TNBC tumors respond to retreatment with PU-H71 for several cycles extending for over 5 months without evidence of resistance or toxicity.
For research only, not for human use!
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