Alda-1 is an ALDH2 agonist, cell-permeable activator of both the wild-type ALDH2*1 and the asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (mtALDH2).
Product Name: Alda-1 |Catalog Number: DC8723 |CAS 349438-38-6 |Other names: ALDA1,ALDA 1 |Chemical Name: |Molecule Formular: C15H11Cl2NO3 |MW: 324.16
Alda-1 is an ALDH2 agonist, cell-permeable activator of both the wild-type ALDH2*1 and the asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (mtALDH2).
in vitro: ALDH2 is the oxidative enzyme, which removes the ethanol metabolite acetaldehyde and other aliphatic aldehydes. Also. ALDH2 is involved in bioconversion of vasodilator nitroglycerin to nitric oxide. Alda-1 increases acetaldehyde oxidation by ALDH2*1 (wild type) and ALDH2*2 9 Asian variant) approximately 1.5- and 6-fold, respectively. Alda-1 stimulates acetaldehyde oxidation by ALDH2 by improving NAD binding. Alda-1 activates wild-type ALDH2 and restores near wild-type activity to ALDH2*2.
in vivo: Alda-1 inhibits atherosclerosis and attenuates NAFLD in apoE-/- mice. The treatment with Alda-1 results in a significant decrease of TG level in liver of apoE-/- mice.
For research and scientific purpose only, not for human use!
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