Acalisib (GS-9820) is a potent and selective inhibitor of PI3Kδ with IC50 value of 12.7 nM.
Product Name: Acalisib |Catalog Number: DC8760 |CAS 870281-34-8 |Other names: UNII-OVW60IDW1D;Acalisib (GS-9820); |Chemical Name: |Molecule Formular: C21H16FN7O |MW: 401.4
Acalisib (GS-9820) inhibits the activity of PI3K, thereby preventing the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), which decreases tumor cell proliferation and induces cell death. Wortmannin, LY294002, GDC0941, IC87114 and Acalisib induced a dramatic retraction of osteoclasts within 15-20 min to 65-75% of the initial area. In contrast, there was no significant retraction in response to vehicle, PIK75, TGX221 or AS252424. Moreover, wortmannin and Acalisib (GS-9820), but not PIK75 or TGX221, disrupted actin belts. Whereas PIK75, TGX221, and Acalisib had no significant effect on basal survival, all blocked RANKL-stimulated survival. PI3K-mediated signaling is often dysregulated in cancer cells; the targeted inhibition of PI3K is designed to preserve PI3K signaling in normal, non-neoplastic cells.
For research only, not for human use!
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