FLLK31 is a potent and selective inhibitor of the STAT3 signaling pathway.
Product Name: FLLL31 |Catalog Number: DC8726 |CAS 52328-97-9 |Other names: FLLL31,FLLL-31,FLLL 31 |Chemical Name: (E,E)-1,7-Bis(3,4-dimethoxyphenyl)-4,4-dimethyl-1,6-heptadiene-3,5-dione Tetramethylcurcumin |Molecule Formular: C25H28O6 |MW: 424.49
FLLL31 selectively binds to Janus kinase 2 and the STAT3 Src homology-2 (SH2) domain, effective inhibitors of STAT3 phosphorylation. STAT3 plays a critical role in early embryogenesis, but is largely dispensable in normal adult cells and tissues. On the other hand the JAK2/STAT3 signaling pathway is persistently activated in great number of human solid and blood cancers. Such activation is commonly associated with a worse prognosis. FLLL31 is a curcumin derivative locked in diketone-tautomeric form, which supposedly improves binding to SH2 domain. The compound inhibits JAK2 kinase activity and prevents STAT3 phosphorylation. FLLK31 is a potent and selective inhibitor of the STAT3 signaling pathway.
For research and scientific purpose only, not for human use!
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