WDR5-0103 is a potent and selective WD repeat-containing protein 5 (WDR5) antagonist with Kd of 450 nM.
Product Name: WDR5-0103 |Catalog Number: DC8662 |CAS 890190-22-4 |Other names: WD-Repeat Protein 5-0103,WDR5 0103,WDR50103 |Chemical Name: |Molecule Formular: C21H25N3O4 |MW: 383.44
WDR5-0103 is a potent and selective WD repeat-containing protein 5 (WDR5) antagonist with Kd of 450 nM.in vitro: WDR5-0103 inhibits MLL catalytic activity with an IC50 value of 39±10 μM. An increase in MLL complex concentration resulted in proportional increase in IC50 values for WDR5-0103 (83±10 and 280±12 μM at concentrations of 500 and 1000 nM of the core trimeric MLL complex respectively). These data are consistent with a mechanism of action in which WDR5-0103 antagonizes the interaction of WDR5 with MLL by competing with MLL for their mutual binding site on WDR5.
For research and scientific purpose only, not for human use!
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