GSK-5959|BRPF1 bromodomain inhibitor|DC Chemicals

GSK-5959|BRPF1 bromodomain  inhibitor|DC Chemicals

GSK 5959 is a potent, cell-permeable inhibitor of the BRPF1 bromodomain (IC50 = 80 nM).

Product Name: GSK 5959 |Catalog Number: DC8360 |CAS 901245-65-6 |Other names: GSK5959,GSK-5959 |Chemical Name: N-[2,3-dihydro-1,3-dimethyl-2-oxo-6-(1-piperidinyl)-1H-benzimidazol-5-yl]-2-methoxy-benzamide |Molecule Formular: C22H26N4O3 |MW: 394.5

The bromodomain and PHD finger-containing (BRPF) proteins are scaffolding components of chromatin-binding MOZ/MORF histone acetyltransferase complexes, which have activity as transcriptional regulators.BRPF1 (BR140 or Peregrin) is important for maintaining Hox gene expression and the development of multiple tissues, axial skeleton, and the hematopoietic system.GSK 5959 is a potent, cell-permeable inhibitor of the BRPF1 bromodomain (IC50 = 80 nM).It exhibits greater than 100-fold selectivity for the BRPF1 bromodomain over a panel of 35 other bromodomains. GSK 5959 disrupts chromatin binding of BRPF1 in a cellular assay by blocking the interaction of BRPF1 with histone H3.3 For the detailed information of GSK 5959, the solubility of GSK 5959 in water, the solubility of GSK 5959 in DMSO, the solubility of GSK 5959 in PBS buffer, the animal experiment (test) of  GSK 5959, the cell expriment (test) of GSK 5959, the in vivo, in vitro and clinical trial test of GSK 5959, the EC50, IC50,and affinity,of GSK 5959, For the detailed information of GSK 5959, the solubility of GSK 5959 in water, the solubility of GSK 5959 in DMSO, the solubility of GSK 5959 in PBS buffer, the animal experiment (test) of  GSK 5959, the cell expriment (test) of GSK 5959, the in vivo, in vitro and clinical trial test of GSK 5959, the EC50, IC50,and affinity,of GSK 5959, Please contact DC Chemicals.

For research and scientific purpose only, not for human use.