Ezutromid|utrophin's translation modulator

Ezutromid|utrophin's translation modulator

Ezutromid is a novel Small utrophin's translation modulator with EC50 of 0.4 uM .

Product Name: Ezutromid|Cat No: DC9821|cas: 945531-77-1|Other Names: SMT C1100; VOX C1100; BMN 195; SMT-C1100; VOX-C1100; BMN-195; BMN195

Ezutromid is a novel Small utrophin's translation modulator with EC50 of 0.4 uM .
In vitro: 1) SMT C1100 induces increased levels of utrophin RNA in human muscle cells.
2) Treatment of human DMD cells with SMT C1100 lead to a 2-fold increase in utrophin protein levels at an optimal concentration of 0.3 uM after 3 days of treatment.
3) SMT C1100 wassafe and well tolerated with plasma concentrations achieved suf?cient to cause a 50% increase in concentrations of utrophin in cells.
4) SMT C1100 led to a 30% increase in Utrn mRNA level and resulted in a 2.0-fold increase in UTRN protein level .
In vivo: 1)The reference for administration is 50 mg/kg.
2) it was considered that no toxicity was determined for SMT C1100 administered by oral gavage to the mouse up to dose levels of 2000 mg/kg/day for 28 days.

For the research and scientific use only, not for human use!