JK184,JK-184||Hh signaling inhibitor

JK184,JK-184||Hh signaling inhibitor

JK-184  is a potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM).

Product Name: JK-184|Cat No: DC9929|cas: 315703-52-7|Other Names: JK184, JK-184

Potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM). Exhibits antiproliferative activity in a range of cancer cell lines (GI50 = 3 - 21 nM) and in human xenografts in vivo. Inhibits alcohol dehydrogenase 7 (Adh7) (IC50 = 210 nM) and acts as a microtubule depolymerizing agent in vitro.

For the research and scientific use only, not for human use!