VER-49009|VER49009|HSP90 inhibitor|DC Chemicals

VER-49009|VER49009|HSP90 inhibitor|DC Chemicals

Consistent with inhibition of Hsp90, VER-49009 induces the expression of Hsp27 and Hsp72 while reducing the client proteins C-RAF, B-RAF, survivin, and PRMT5, causing cell cycle arrest and apoptosis.

Product Name: VER-49009 |Catalog Number: DC8477 |CAS 940289-57-6 |Other names: VER-49009,VER 49009,VER49009 |Chemical Name: 3-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-1H-pyrazole-5-carboxamide |Molecule Formular: C19H18ClN3O4 |MW: 387.82

VER-49009 is a potent HSP90 inhibitor. VER-49009 inhibits Hsp90 with an IC50 value of 47 nM. VER-49009 produces a cellular antiproliferative GI50 value of 685 nM when tested against a human cancer cell line panel. Consistent with inhibition of Hsp90, VER-49009 induces the expression of Hsp27 and Hsp72 while reducing the client proteins C-RAF, B-RAF, survivin, and PRMT5, causing cell cycle arrest and apoptosis

For research and scientific purpose only, not for human use.