STF-083010|cas 307543-71-1|DC Chemicals

STF-083010|cas 307543-71-1|DC Chemicals

STF-083010 is a specific IRE1α endonuclease inhibitor.

Product Name: STF-083010 |Catalog Number: DC8413 |CAS 307543-71-1 |Other names: STF-083010,STF083010,STF 083010 |Chemical Name: (E)-N-((2-hydroxynaphthalen-1-yl)methylene)thiophene-2-sulfonamide |Molecule Formular: C15H11NO3S2 |MW: 317.38

In RPMI 8226, MM.1S, and MM.1R MM cell lines, STF-083010 exhibits cytostatic and cytotoxic activity in a dose and time dependent manner. [1] [2] In MiaPaCa2, Panc0403, and SU8686 cell lines, STF-083010 inhibits XBP1 splicing and blocks IRE1α's endonuclease activity without affecting its kinase activity. [1] In Eμ-TCL1 CLL cells, STF-083010 exhibits about 70% growth inhibition after 3 days culture. In MEC1 and MEC2 cells, STF-083010 produces 20% growth inhibition in 48 h. WaC3 cells respond to treatments with STF-083010 with gradually decreased growth. [3]In human multiple myeloma (MM) xenografts model, STF-083010 (i.p., 30 mg/kg) significantly inhibits the growth of tumor. [1] For the detailed information of STF-083010, the solubility of STF-083010 in water, the solubility of STF-083010 in DMSO, the solubility of STF-083010 in PBS buffer, the animal experiment (test) of  STF-083010, the cell expriment (test) of STF-083010, the in vivo, in vitro and clinical trial test of STF-083010, the EC50, IC50,and affinity,of STF-083010, For the detailed information of STF-083010, the solubility of STF-083010 in water, the solubility of STF-083010 in DMSO, the solubility of STF-083010 in PBS buffer, the animal experiment (test) of  STF-083010, the cell expriment (test) of STF-083010, the in vivo, in vitro and clinical trial test of STF-083010, the EC50, IC50,and affinity,of STF-083010, Please contact DC Chemicals.

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