Smoothened Agonist (SAG) HCl|cas 912545-86-9(free base)|DC Chemicals

Smoothened Agonist (SAG) HCl|cas 912545-86-9(free base)|DC Chemicals

Smoothened Agonist (SAG) HCl is a cell-permeable Smoothened (Smo) agonist with EC50 of 3 nM in Shh-LIGHT2 cells.

Product Name: Smoothened Agonist (SAG) HCl |Catalog Number: DC8391 |CAS 912545-86-9(free base) |Other names:  |Chemical Name: N-(3-(pyridin-4-yl)benzyl)-3-chloro-N-((1r,4r)-4-(methylamino)cyclohexyl)benzo[b]thiophene-2-carboxamide hydrochloride |Molecule Formular: C28H29Cl2N3OS |MW: 526.52

SAG regulates Smo activity by binding directly to the Smo heptahelical bundle. [1] SAG induces Smo-dependent signaling through Gli in a GRK2-dependent way. [2] SAG also (1 nM) induces proliferation of neuronal and glial precursors without affecting the differentiation pattern of newly produced cells. [3]In the adult rat hippocampus, the intracerebroventricular administration of SAG (2.5 nM) significantly increases the number of newly generated cells and extends survival of hippocampal cells. [3] In mice, SAG (20 μg/g, i.p.) effectively prevents GC-induced neonatal cerebellar developmental abnormalities. [4] For the detailed information of Smoothened Agonist (SAG) HCl, the solubility of Smoothened Agonist (SAG) HCl in water, the solubility of Smoothened Agonist (SAG) HCl in DMSO, the solubility of Smoothened Agonist (SAG) HCl in PBS buffer, the animal experiment (test) of  Smoothened Agonist (SAG) HCl, the cell expriment (test) of Smoothened Agonist (SAG) HCl, the in vivo, in vitro and clinical trial test of Smoothened Agonist (SAG) HCl, the EC50, IC50,and affinity,of Smoothened Agonist (SAG) HCl, For the detailed information of Smoothened Agonist (SAG) HCl, the solubility of Smoothened Agonist (SAG) HCl in water, the solubility of Smoothened Agonist (SAG) HCl in DMSO, the solubility of Smoothened Agonist (SAG) HCl in PBS buffer, the animal experiment (test) of  Smoothened Agonist (SAG) HCl, the cell expriment (test) of Smoothened Agonist (SAG) HCl, the in vivo, in vitro and clinical trial test of Smoothened Agonist (SAG) HCl, the EC50, IC50,and affinity,of Smoothened Agonist (SAG) HCl, Please contact DC Chemicals.

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