SGI7079|cas 1239875-86-5|DC Chemicals

SGI7079|cas 1239875-86-5|DC Chemicals

SGI-7079 is a novel Axl inhibitor.

Product Name: SGI7079 |Catalog Number: DC8535 |CAS 1239875-86-5 |Other names:  |Chemical Name:  |Molecule Formular: C26H26FN7 |MW: 455.53

SGI-7079 is a novel Axl inhibitor. SGI-7079 decreased IBC cell proliferation, migration and invasion in vitro and inhibited tumor growth of IBC cells in vivo. Mesenchymal cells also expressed increased levels of the receptor tyrosine kinase Axl and showed a trend toward greater sensitivity to the Axl inhibitor SGI-7079, whereas the combination of SGI-7079 with erlotinib reversed erlotinib resistance in mesenchymal lines expressing Axl and in a xenograft model of mesenchymal NSCLC.

For research and scientific purpose only, not for human use.