SAR131675|cas 1092539-44-0|DC Chemicals

SAR131675|cas 1092539-44-0|DC Chemicals

SAR131675 is a potent and selective VEGFR-3 inhibitor.

Product Name: SAR131675 |Catalog Number: DC8530 |CAS 1092539-44-0 |Other names: SAR131675 |Chemical Name:  |Molecule Formular: C18H22N4O4 |MW: 358.4

SAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells with IC(50) values of 20 and 45nM, respectively. SAR131675 dose dependently inhibited the proliferation of primary human lymphatic cells, induced by the VEGFR-3 ligands VEGFC and VEGFD, with an IC(50) of about 20nM. SAR131675 was found to be highly selective for VEGFR-3 versus 107 receptors, enzymes, ion channels, and 65 kinases. However, it was moderately active on VEGFR-2 with a VEGFR-3/VEGFR-2 ratio of about 10. SAR131675 had no antiproliferative activity on a panel of 30 tumors and primary cells, further showing its high specificity and indicating that SAR131675 is not a cytotoxic or cytostatic agent.

For research and scientific purpose only, not for human use.