Picropodophyllin (PPP)|cas 477-47-4|DC Chemicals

Picropodophyllin (PPP)|cas 477-47-4|DC Chemicals

Picropodophyllin (PPP) is a selective IGF-1R inhibitor with IC50 of 1 nM. Phase 1/2.

Product Name: Picropodophyllin (PPP) |Catalog Number: DC8426 |CAS 477-47-4 |Other names:  |Chemical Name: (5R,5aS,8aR,9R)-5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one |Molecule Formular: C22H22O8 |MW: 414.41

In intact cells, PPP efficiently inhibits IGF-1-stimulated IGF-1R, Akt (Ser 473) and Erk1/2 phosphorylation. Picropodophyllin specifically inhibits cell growth, and induces apoptosis in cultured IGF-1R-positive tumor cells. [1] Picropodophyllin synergistically sensitizes HMCL, primary human MM and murine 5T33MM cells to ABT-737 and ABT-199 by further decreasing cell viability and enhancing apoptosis. [3] Picropodophyllin and sorafenib synergistically suppress the proliferation and motility of hepatocellular carcinoma cells. [4]In SCID mice xenografted with human ES-1, BE, and PC3, Picropodophyllin (20 mg/kg/12 h, i.p.) causes complete tumor regression. [1] In the 5T33MM mouse model, Picropodophyllin also shows a marked antitumor activity, and causes a significant increase in survival. [2] For the detailed information of Picropodophyllin (PPP), the solubility of Picropodophyllin (PPP) in water, the solubility of Picropodophyllin (PPP) in DMSO, the solubility of Picropodophyllin (PPP) in PBS buffer, the animal experiment (test) of  Picropodophyllin (PPP), the cell expriment (test) of Picropodophyllin (PPP), the in vivo, in vitro and clinical trial test of Picropodophyllin (PPP), the EC50, IC50,and affinity,of Picropodophyllin (PPP), For the detailed information of Picropodophyllin (PPP), the solubility of Picropodophyllin (PPP) in water, the solubility of Picropodophyllin (PPP) in DMSO, the solubility of Picropodophyllin (PPP) in PBS buffer, the animal experiment (test) of  Picropodophyllin (PPP), the cell expriment (test) of Picropodophyllin (PPP), the in vivo, in vitro and clinical trial test of Picropodophyllin (PPP), the EC50, IC50,and affinity,of Picropodophyllin (PPP), Please contact DC Chemicals.

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