ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B.
Product Name: ML167 |Catalog Number: DC8594 |CAS 1285702-20-6 |Other names: ML167; ML-167; ML 167; CID 44968231 |Chemical Name: |Molecule Formular: C19H17N3O3 |MW: 335.35658
The Cdc2-like kinases (Clks) and the dual-specificity tyrosine phosphorylation-regulated kinases (Dyrks) are involved in regulating gene splicing. Clks phosphorylate serine/arginine-rich proteins, which are a major component of the spliceosome, whereas Dyrks interact with and activate splicing factors. ML167 is a selective, ATP-competitive inhibitor of Clk4 with an IC50 value of 136 nM. It is more than 10-fold less active against the closely related kinases Clk1-3, Dyrk1A, and Dyrk1B (IC50s = 1.5, 1.6, >10, >10, and 4.4 µM, respectively), and minimally active against a panel of other kinases.
For research and scientific purpose only, not for human use.
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