FTI 277 HCl|cas 180977-34-8|DC Chemicals

FTI 277 HCl|cas 180977-34-8|DC Chemicals

FTI 277 HCl is the methyl ester of FTI 277, which is a potent and selective farnesyltransferase (FTase) inhibitor with IC50 of 500 pM, about 100-fold selectivity over the closely related GGTase I.

Product Name: FTI 277 HCl |Catalog Number: DC8421 |CAS 180977-34-8 |Other names: FTI277,FTI-277,FTI 277 |Chemical Name: 4-[2(R)-amino-3-mercaptopropyl]amino-2-phenylbenzoyl-(S)-methionine methyl ester hydrochloride |Molecule Formular: C22H30ClN3O3S2 |MW: 484.07

FTI-277 inhibits Ras processing with an IC50 of 100 nM, but not the geranylgeranylated Rap1A processing in whole cells. FTI-277 induces accumulation of cytoplasmic non-farnesylated H-Ras, accumulates inactive Ras/Raf complexes in the cytoplasm, and blocks constitutive MAPK activation in H-RasF cells. [1] FTI-277 causes increased apoptosis after irradiation and increases radiosensitivity in H-ras-transformed rat embryo cells. [2] FTI-277 also inhibits cell growth and induces apoptosis in drug-resistant myeloma tumor cells. [3] In SH-SY5Y cells, FTI-277 diminishes the toxic effects of methamphetamine on induction in cell degeneration, activation in c-Jun-N-terminal kinase cascades, and Ras activation. [4]In mice coinfected with hepatitis B virus (HBV) and HDV, FTI-277 (50 mg/kg/d i.p.) effectively clears HDV viremia. [5] For the detailed information of FTI 277 HCl, the solubility of FTI 277 HCl in water, the solubility of FTI 277 HCl in DMSO, the solubility of FTI 277 HCl in PBS buffer, the animal experiment (test) of  FTI 277 HCl, the cell expriment (test) of FTI 277 HCl, the in vivo, in vitro and clinical trial test of FTI 277 HCl, the EC50, IC50,and affinity,of FTI 277 HCl, For the detailed information of FTI 277 HCl, the solubility of FTI 277 HCl in water, the solubility of FTI 277 HCl in DMSO, the solubility of FTI 277 HCl in PBS buffer, the animal experiment (test) of  FTI 277 HCl, the cell expriment (test) of FTI 277 HCl, the in vivo, in vitro and clinical trial test of FTI 277 HCl, the EC50, IC50,and affinity,of FTI 277 HCl, Please contact DC Chemicals.

For research and scientific purpose only, not for human use.