EW-7197|EW-7197|ALK5 inhibitor|DC Chemicals

EW-7197|EW-7197|ALK5 inhibitor|DC Chemicals

EW-7197  is a potent ALK5 inhibitor. EW-7197 showed potent in vivo anti-metastatic activity, indicating its potential for use as an anti-cancer therapy.

Product Name: EW-7197 |Catalog Number: DC8342 |CAS 1352608-82-2(EW-7197); 1352610-25-3 (EW-7197 HCl salt) |Other names: EW-7197，EW 7197，EW7197 |Chemical Name: N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline |Molecule Formular: C22H18FN7 |MW: 399.42

EW-7197  is a potent ALK5 inhibitor. EW-7197 showed potent in vivo anti-metastatic activity, indicating its potential for use as an anti-cancer therapy. EW-7197 inhibits TGF-β/Smad signaling. EW-7197 abrogates TGF-β1-induced tumor cell migration and invasion. EW-7197 inhibits breast cancer metastasis to the lung.EW-7197 prolongs the life span of BALB/c 4T1 mice via inhibition of EMT. EW-7197 inhibits metastasis and enhances the activity of cytotoxic T lymphocytes
(CTLs) in 4T1 orthotopic grafted mice. For the detailed information of EW-7197, the solubility of EW-7197 in water, the solubility of EW-7197 in DMSO, the solubility of EW-7197 in PBS buffer, the animal experiment (test) of  EW-7197, the cell expriment (test) of EW-7197, the in vivo, in vitro and clinical trial test of EW-7197, the EC50, IC50,and affinity,of EW-7197, For the detailed information of EW-7197, the solubility of EW-7197 in water, the solubility of EW-7197 in DMSO, the solubility of EW-7197 in PBS buffer, the animal experiment (test) of  EW-7197, the cell expriment (test) of EW-7197, the in vivo, in vitro and clinical trial test of EW-7197, the EC50, IC50,and affinity,of EW-7197, Please contact DC Chemicals.

For research and scientific purpose only, not for human use.