Dyngo-4a|cas 1256493-34-1|DC Chemicals

Dyngo-4a|cas 1256493-34-1|DC Chemicals

Dyngo-4a is a potent dynamin inhibitor with IC50 of 0.38 μM, 1.1 μM, and 2.3 μM for DynI (brain), DynI (rec), and DynII (rec), respectively.

Product Name: Dyngo-4a |Catalog Number: DC8396 |CAS 1256493-34-1 |Other names:  |Chemical Name: (E)-N'-(2,4,5-trihydroxybenzylidene)-3-hydroxy-2-naphthohydrazide |Molecule Formular: C18H14N2O5 |MW: 338.31

Dyngo-4a inhibits dynamin-dependent endocytosis of transferrin in multiple cell types with IC₅₀ of 5.7 μM, and reduces synaptic vesicle endocytosis and activity-dependent bulk endocytosis in cultured neurons and synaptosomes. [1] In motor nerve terminals and cultured hippocampal neurons, Dyngo-4a blocks Alexa Fluor 488-BoNT/A-Hc internalization. [2] In Drosophila S2R+ cells, Dyngo-4a causes a decrease in the level of Armadillo/β-catenin. [3] For the detailed information of Dyngo-4a, the solubility of Dyngo-4a in water, the solubility of Dyngo-4a in DMSO, the solubility of Dyngo-4a in PBS buffer, the animal experiment (test) of  Dyngo-4a, the cell expriment (test) of Dyngo-4a, the in vivo, in vitro and clinical trial test of Dyngo-4a, the EC50, IC50,and affinity,of Dyngo-4a, For the detailed information of Dyngo-4a, the solubility of Dyngo-4a in water, the solubility of Dyngo-4a in DMSO, the solubility of Dyngo-4a in PBS buffer, the animal experiment (test) of  Dyngo-4a, the cell expriment (test) of Dyngo-4a, the in vivo, in vitro and clinical trial test of Dyngo-4a, the EC50, IC50,and affinity,of Dyngo-4a, Please contact DC Chemicals.

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