Cyclo(RGDyK)|cas 250612-42-1|DC Chemicals

Cyclo(RGDyK)|cas 250612-42-1|DC Chemicals

Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.

Product Name: Cyclo(RGDyK) |Catalog Number: DC8399 |CAS 250612-42-1 |Other names:  |Chemical Name: cyclo(L-arginylglycyl-L-α-aspartyl-D-tyrosyl-L-lysyl), 2,2,2-trifluoroacetate (1:2) |Molecule Formular: C31H43F6N9O12 |MW: 847.72

Cyclo(RGDyK) shows high affinity and selectivity for αVβ3 over αVβ5 and αIIbβ3. [1] Cyclo(RGDyK)-conjugated micelles (TPM) facilitated the cell-specific uptake of DiI into B16-F10 cells and HUVECs via integrin-mediated endocytosis compared with Cyclo(RGDyK) -free micelles (NPM). [2]In apoE−/− mice, Cyclo(RGDyK) (1 nmol, i.v.) inhibits the increase of αVβ3 integrin expression in the intima of the left stenotic carotid artery. [2] For the detailed information of Cyclo(RGDyK), the solubility of Cyclo(RGDyK) in water, the solubility of Cyclo(RGDyK) in DMSO, the solubility of Cyclo(RGDyK) in PBS buffer, the animal experiment (test) of  Cyclo(RGDyK), the cell expriment (test) of Cyclo(RGDyK), the in vivo, in vitro and clinical trial test of Cyclo(RGDyK), the EC50, IC50,and affinity,of Cyclo(RGDyK), For the detailed information of Cyclo(RGDyK), the solubility of Cyclo(RGDyK) in water, the solubility of Cyclo(RGDyK) in DMSO, the solubility of Cyclo(RGDyK) in PBS buffer, the animal experiment (test) of  Cyclo(RGDyK), the cell expriment (test) of Cyclo(RGDyK), the in vivo, in vitro and clinical trial test of Cyclo(RGDyK), the EC50, IC50,and affinity,of Cyclo(RGDyK), Please contact DC Chemicals.

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