BRD7552|cas 1137359-47-7|DC Chemicals

BRD7552|cas 1137359-47-7|DC Chemicals

BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression.

Product Name: BRD7552 |Catalog Number: DC8409 |CAS 1137359-47-7 |Other names: BRD 7552,BRD-7552,BRD7552 |Chemical Name: ethyl 4-(((2R,3R,4S,5R,6S)-4,5-bis(benzo[d][1,3]dioxol-5-ylcarbamoyloxy)-2-(hydroxymethyl)-6-methoxy-tetrahydro-2H-pyran-3-yloxy)carbonyl)benzoate |Molecule Formular: C33H33N3O15 |MW: 711.63

BRD7552 upregulates PDX1 expression in both primary human islets and ductal cells, and induces epigenetic changes in the PDX1 promoter consistent with transcriptional activation. BRD7552 increases PDX1 mRNA levels by 2- to 4-fold, with a maximal effect at 5 μM and the expression of MAFA. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells. Treatment of PANC-1 cells with BRD7552 causes a dose-dependent increase in insulin mRNA expression. [1] For the detailed information of  BRD7552, the solubility of  BRD7552 in water, the solubility of  BRD7552 in DMSO, the solubility of  BRD7552 in PBS buffer, the animal experiment (test) of   BRD7552, the cell expriment (test) of  BRD7552, the in vivo, in vitro and clinical trial test of  BRD7552, the EC50, IC50,and affinity,of  BRD7552, For the detailed information of  BRD7552, the solubility of  BRD7552 in water, the solubility of  BRD7552 in DMSO, the solubility of  BRD7552 in PBS buffer, the animal experiment (test) of   BRD7552, the cell expriment (test) of  BRD7552, the in vivo, in vitro and clinical trial test of  BRD7552, the EC50, IC50,and affinity,of  BRD7552, Please contact DC Chemicals.

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