Tyrphostin AG 879 is a protein tyrosine kinase inhibitor with potent effects on TrkA.
Product Name: AG879 |Catalog Number: DC8557 |CAS 148741-30-4 |Other names: AG 879,AG-879 |Chemical Name: 2-Propenethioamide, 3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-, (2E)- |Molecule Formular: C18H24N2OS |MW: 316.46
Tyrphostin AG 879 is a protein tyrosine kinase inhibitor with potent effects on TrkA. This product reportedly inhibits NGF-induced PLC-γ 1 phosphorylation and phosphatidylinositol-3 kinase activation. Has been shown in lab studies to disrupt Sertoli cell aggregation and stop androgen-induced cell proliferation. AG 879 also displays anti-cancer effects by inhibiting the expression of RAF-1 gene encoding MAP kinase activity necessary for human breast cancer cell proliferation. Shown to inhibit Neu (HER-2 or ERBB2) expression and reduced tumor sizes in mice leukemia cells. Tyrphostin AG 879 is an inhibitor of Flk-1.
For research and scientific purpose only, not for human use.
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