S1RA HCl|cas 1265917-14-3|DC Chemicals

S1RA HCl|cas 1265917-14-3|DC Chemicals

S1RA(E-52862) is a potent and selective sigma-1 receptor(σ1R, Ki=17 nM), showed good selectivity against σ2R (Ki > 1000 nM).

Product Name: S1RA hydrochloride|Cat No. DC9264|cas: 1265917-14-3|Other names: E-52862; E52862; E 52862| Molecule formular: C20H24ClN3O2Molecule Weight: 373.88

S1RA, E-52862, or 4-(2-((5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yl)oxy)ethyl)morpholine is a selective sigma-1 receptor antagonist, with a reported binding affinity of Ki = 17.0 ± 7.0 nM, selective over the sigma-2 receptor and against a panel of other 170 receptors, enzymes, transporters and ion channels.[1][2] In preclinical studies, S1RA has demonstrated efficacy in relieving neuropathic pain and pain in other sensitizing conditions, associated with an improvement of the emotional negative state.For the detailed information of S1RA, the solubility of S1RA in water, the solubility of S1RA in DMSO, the solubility of S1RA in PBS buffer, the animal experiment (test) of  S1RA, the cell expriment (test) of S1RA, the in vivo, in vitro and clinical trial test of S1RA, the EC50, IC50,and Affinity of S1RA, Please contact DC Chemicals.

For research only, not for human use.