C-DIM12|cas 178946-89-9 |DC Chemicals

C-DIM12|cas 178946-89-9 |DC Chemicals

C-DIM12 is a novel synthetic activator of Nurr1.

Product Name: C-DIM12|Cat No. DC9277|cas: 178946-89-9|Other names: | Molecule formular: C23H17ClN2Molecule Weight: 356.11

C-DIM12 is a novel synthetic activator of Nurr1. C-DIM12 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro. C-DIM12 activates Nurr1 in cancer cells and prevents loss of dopaminergic neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of PD in mice. C-DIM12 induced expression of Nurr1-regulated genes that was abolished by Nurr1 knockdown. C-DIM12 increased expression of transfected human Nurr1, induced Nurr1 protein expression in primary dopaminergic neurons and enhanced neuronal survival from exposure to 6-OHDA. C-DIM12 stimulates neuroprotective expression Nurr1-regulated genes in DA neurons.