MCC950 (CP-456773) sodium|cas 256373-96-3|DC Chemicals

MCC950 (CP-456773) sodium|cas 256373-96-3|DC Chemicals

MCC950 (CP-456773) sodium is a potent, selective, small-molecule inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs.

Product Name: MCC950 (CP-456773) sodium|Cat No. DC9254|cas: 256373-96-3|Other names: CP-456773 sodium; CRID3 sodium salt; MCC-950 sodium; CP456773 sodium; CRID-3 sodium salt| Molecule formular: C20H23N2NaO5SMolecule Weight: 426.46

MCC950 blocked canonical and noncanonical NLRP3 activation at nanomolar concentrations. MCC950 specifically inhibited activation of NLRP3 but not the AIM2, NLRC4 or NLRP1 inflammasomes. MCC950 reduced interleukin-1β (IL-1β) production in vivo and attenuated the severity of experimental autoimmune encephalomyelitis (EAE), a disease model of multiple sclerosis. Furthermore, MCC950 treatment rescued neonatal lethality in a mouse model of CAPS and was active in ex vivo samples from individuals with Muckle-Wells syndrome. MCC950 is thus a potential therapeutic for NLRP3-associated syndromes, including autoinflammatory and autoimmune diseases, and a tool for further study of the NLRP3 inflammasome in human health and disease.