K 858 |cas 72926-24-0|DC Chemicals

K 858 |cas 72926-24-0|DC Chemicals

K 858 is an ATP-uncompetitive mitotic kinesin Eg5 inhibitor, which does not effect microtubule dynamics.

Product Name: K 858|Cat No. DC9272|cas: 72926-24-0|Other names: K858,K-858| Molecule formular: C13H15N3O2SMolecule Weight: 277.34

K 858 is an ATP-uncompetitive mitotic kinesin Eg5 inhibitor, which does not effect microtubule dynamics. Studies on HCT116 cells indicate that K 858 causes mitotic arrest, cell growth inhibition, and activates caspase-3. It is also believed that K858 inhibits the growth of cancer cells. Studies suggest that K 858 is not neurotoxic in motor coordination. Furthermore, K 858 can be a beneficial tool because unlike similar compounds that inhibit Eg5, K 858 does not form breaks in double stranded DNA.