ABT-719|cas 162763-53-3|DC Chemicals

ABT-719|cas 162763-53-3|DC Chemicals

ABT-719 is a potent bacterial DNA gyrase inhibitor.

Product Name: ABT-719 HCl|Cat No. DC9261|cas: 162763-53-3|Other names: ABT-719,ABT 719,ABT719,A-86719.1| Molecule formular: C18H20FN3O3.HClMolecule Weight: 381.83

ABT-719 is an S isomer and a representative 2-pyridone. ABT-719 administered orally or subcutaneously was 4- to 10-fold more effective than ciprofloxacin against Staphylococcus aureus, Streptococcus pneumoniae, and Streptococcus pyogenes infections in normal mice. ABT-719 was equivalent in efficacy to ciprofloxacin for treatment of gram-negative bacterial infections caused by Pseudomonas aeruginosa or Escherichia coli. The racemate and R forms of ABT-719 produced similar results against gram-positive and gram-negative bacterial infections. The 50% effective doses of ABT-719 were at least threefold lower than those of ciprofloxacin for therapy of intracellular infections caused by Salmonella typhimurium or Listeria monocytogenes. In immunosuppressed mice, ABT-719 was more effective than ciprofloxacin against quinolone-sensitive S. aureus, Enterococcus faecalis, and Enterococcus faecium. The pharmacokinetic properties of ABT-719 were consistent with its relative efficacy.